Simultaneous UPLC analysis of three major flavonoids in granule decoctions of Fructus Aurantii-type formulae

被引：7

作者：

Huang, Wei ^{[1
,2
,3
]}

Xiong, Zhi-Hua ^{[1
,2
]}

Huang, Xi ^{[1
,2
,3
]}

Chen, Xiao ^{[4
]}

Liu, Wei-Ping ^{[1
,2
]}

Wang, Yang ^{[1
,2
,3
]}

Ren, Ping ^{[1
,2
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Inst Integrated Tradit Med & Western Med, Lab Ethnopharmacol, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Natl Key Clin Specialist Vocat Sch TCM Encephalop, Changsha, Hunan, Peoples R China

[3] Cent S Univ, TCM Pharmacogenet Lab, Changsha, Hunan, Peoples R China

[4] Jiangxi Qingfeng Pharmaceut Co Ltd, Ganzhou, Peoples R China

来源：

PHARMAZIE | 2012年 / 67卷 / 07期

关键词：

CONSTITUENTS; NARINGIN;

D O I：

10.1691/ph.2012.1142

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A simple, rapid, and sensitive liquid chromatographic method has been established for the simultaneous analysis of three compounds (narirutin, hesperidin and naringin), in granule decoctions of Fructus Aurantii-type formulae. The compounds were separated in less than 10 min using a C18 column with gradient elution using (A) acetonitrile, (B) water, and (C) acetic acid at a flow rate of 0.3 mL/min, and with a PDA detector. The method was validated for specificity, accuracy, precision, and limits of detection. Good linear regression data (r2 > 0.9980) were obtained for all the calibration plots within the ranges tested. The method is an attractive alternative for quality control and clinical monitor of granule decoctions of Fructus Aurantii-type formulae.

引用

页码：586 / 589

页数：4

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