A case of acute eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression and response to all-trans retinoic acid

被引：11

作者：

Yu, RQ ^{[1
]}

Huang, W ^{[1
]}

Chen, SJ ^{[1
]}

Jiang, SD ^{[1
]}

Chen, Z ^{[1
]}

机构：

[1] SHANGHAI INST HEMATOL,MOL BIOL LAB,SHANGHAI,PEOPLES R CHINA

来源：

LEUKEMIA | 1997年 / 11卷 / 04期

关键词：

leukemia; eosinophilic; PML-RAR alpha; retinoic acid; ACUTE PROMYELOCYTIC LEUKEMIA; POLYMERASE CHAIN-REACTION; TRANSLOCATION; T(15-17); ISOFORMS;

D O I：

10.1038/sj.leu.2400600

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A typical case of eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression is reported. The patient achieved complete remission after oral administration of all-trans retinoic acid without any exposure to cytotoxic agents. The facts strongly suggest that the genetic event occurred at the level of pluripotent stem cells.

引用

页码：609 / 611

页数：3

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