Cutting Edge: Novel Vaccination Modality Provides Significant Protection against Mucosal Infection by Highly Pathogenic Simian Immunodeficiency Virus

被引：35

作者：

Strbo, Natasa ^{[1
,2
]}

Vaccari, Monica ^{[3
]}

Pahwa, Savita ^{[1
,2
]}

Kolber, Michael A. ^{[2
,4
]}

Doster, Melvin N. ^{[3
]}

Fisher, Eva ^{[1
]}

Gonzalez, Louis ^{[1
,2
]}

Stablein, Donald ^{[5
]}

Franchini, Genoveffa ^{[3
]}

Podack, Eckhard R. ^{[1
,2
,4
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

[2] Univ Miami, Miller Sch Med, Ctr AIDS Res, Miami, FL 33136 USA

[3] NCI, Anim Models & Retroviral Vaccines Sect, NIH, Bethesda, MD 20817 USA

[4] Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33136 USA

[5] EMMES Corp, Rockville, MD 20850 USA

来源：

JOURNAL OF IMMUNOLOGY | 2013年 / 190卷 / 06期

基金：

美国国家卫生研究院;

关键词：

SHOCK-PROTEIN GP96; RHESUS-MONKEYS; IMMUNE-RESPONSES; DENDRITIC CELLS; CHALLENGE; RECEPTOR; SIV; EFFICACY; VACCINES;

D O I：

10.4049/jimmunol.1202655

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccine-induced protection against infection by HIV or highly pathogenic and virulent SIV strains has been limited. In a proof-of-concept study, we show that a novel vaccine approach significantly protects rhesus macaques from mucosal infection by the highly pathogenic strain SIVmac251. We vaccinated three cohorts of 12 macaques each with live, irradiated vaccine cells secreting the modified endoplasmic reticulum chaperone gp(96)-Ig. Cohort 1 was vaccinated with cells secreting gp96(SIV)Ig carrying SIV peptides. In addition, Cohort 2 received recombinant envelope protein SIV-gp120. Cohort 3 was injected with cells secreting gp(96)-Ig (no SIV Ags) vaccines. Cohort 2 was protected from infection. After seven rectal challenges with highly pathogenic SIVmac251, the hazard ratio was 0.27, corresponding to a highly significant, 73% reduced risk for viral acquisition. The apparent success of the novel vaccine modality recommends further study. The Journal of Immunology, 2013, 190: 2495-2499.

引用

页码：2495 / 2499

页数：5

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