Sonoporation: Mechanistic insights and ongoing challenges for gene transfer

被引：207

作者：

Delalande, Anthony ^{[1
]}

Kotopoulis, Spiros ^{[2
]}

Postema, Michiel ^{[2
]}

Midoux, Patrick ^{[1
]}

Pichon, Chantal ^{[1
]}

机构：

[1] CNRS, Ctr Biophys Mol, Orleans, France

[2] Univ Bergen, Dept Phys & Technol, Bergen, Norway

来源：

GENE | 2013年 / 525卷 / 02期

关键词：

Ultrasound; Microbubbles; Physical gene delivery method; Gene therapy; ULTRASOUND-EXPOSED MICROBUBBLES; DRUG-DELIVERY; TARGETED DELIVERY; PLASMID DNA; IN-VIVO; THERAPEUTIC APPLICATIONS; MEMBRANE DISRUPTION; FOCUSED ULTRASOUND; LIPOSOMAL BUBBLES; ENDOTHELIAL-CELLS;

D O I：

10.1016/j.gene.2013.03.095

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Microbubbles first developed as ultrasound contrast agents have been used to assist ultrasound for cellular drug and gene delivery. Their oscillation behavior during ultrasound exposure leads to transient membrane permeability of surrounding cells, facilitating targeted local delivery. The increased cell uptake of extracellular compounds by ultrasound in the presence of microbubbles is attributed to a phenomenon called sonoporation. In this review, we summarize current state of the art concerning microbubble-cell interactions and cellular effects leading to sonoporation and its application for gene delivery. Optimization of sonoporation protocol and composition of microbubbles for gene delivery are discussed. (C) 2013 Elsevier B.V. All rights reserved.

引用

收藏

页码：191 / 199

页数：9

相关论文

共 60 条

[1]

Therapeutic ultrasound promotes plasmid DNA uptake by clathrin-mediated endocytosis [J].

Bentes de Paula, Daisy Maria ;

Valero-Lapchik, Valderez Bastos ;

Paredes-Gamero, Edgar Julian ;

Han, Sang Won .

JOURNAL OF GENE MEDICINE, 2011, 13 (7-8) :392-401

[2]

Transient permeabilization of cell membranes by ultrasound-exposed microbubbles is related to formation of hydrogen peroxide [J].

Juffermans, L. J. M. ;

Dijkmans, P. A. ;

Musters, R. J. P. ;

Visser, C. A. ;

Kamp, O. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 291 (04) :H1595-H1601

[3]

Juffermans L J M, 2009, Neth Heart J, V17, P82

[4]

Low-intensity ultrasound-exposed microbubbles provoke local hyperpolarization of the cell membrane via activation of BKCa channels [J].

Juffermans, Lynda J. M. ;

Kamp, Otto ;

Dijkmans, Pieter A. ;

Visser, Cees A. ;

Musters, Rene J. P. .

ULTRASOUND IN MEDICINE AND BIOLOGY, 2008, 34 (03) :502-508

[5]

Transient Transmembrane Release of Green Fluorescent Proteins With Sonoporation [J].

Kaddur, Kadija ;

Lebegue, Loic ;

Tranquart, Francois ;

Midoux, Patrick ;

Pichon, Chantal ;

Bouakaz, Ayache .

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2010, 57 (07) :1558-1567

[6]

SONOPORATION BY ULTRASOUND-ACTIVATED MICROBUBBLE CONTRAST AGENTS: EFFECT OF ACOUSTIC EXPOSURE PARAMETERS ON CELL MEMBRANE PERMEABILITY AND CELL VIABILITY [J].

Karshafian, Raffi ;

Bevan, Peter D. ;

Williams, Ross ;

Samac, Sanya ;

Burns, Peter N. .

ULTRASOUND IN MEDICINE AND BIOLOGY, 2009, 35 (05) :847-860

[7]

Enhanced in vivo bioluminescence imaging using liposomal luciferin delivery system [J].

Kheirolomoom, Azadeh ;

Kruse, Dustin E. ;

Qin, Shengping ;

Watson, Katherine E. ;

Lai, Chun-Yen ;

Young, Lawrence J. T. ;

Cardiff, Robert D. ;

Ferrara, Katherine W. .

JOURNAL OF CONTROLLED RELEASE, 2010, 141 (02) :128-136

[8]

Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound [J].

Kinoshita, M ;

McDannold, N ;

Jolesz, FA ;

Hynynen, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 340 (04) :1085-1090

[9]

Ultrasound molecular imaging with targeted microbubble contrast agents [J].

Klibanov, Alexander L. .

JOURNAL OF NUCLEAR CARDIOLOGY, 2007, 14 (06) :876-884

[10]

ULTRASOUND-ENHANCED POLYMER DEGRADATION AND RELEASE OF INCORPORATED SUBSTANCES - (CONTROLLED RELEASE DRUG DELIVERY SYSTEMS) [J].

KOST, J ;

LEONG, K ;

LANGER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :7663-7666

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