Protective role of interleukin-12 in viral myocarditis

被引：42

作者：

Shioi, T ^{[1
]}

Matsumori, A ^{[1
]}

Nishio, R ^{[1
]}

Ono, K ^{[1
]}

Kakio, T ^{[1
]}

Sasayama, S ^{[1
]}

机构：

[1] KYOTO UNIV, DEPT CARDIOVASC MED, SAKYO KU, KYOTO 606, JAPAN

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1997年 / 29卷 / 09期

关键词：

myocarditis; interleukin-12; cytokine; heart failure; virus;

D O I：

10.1006/jmcc.1997.0445

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The co-ordinate action of several cytokines determines the nature, severity and duration of myocarditis. Interkeukin (IL)-12 mediates a broad range of effects on both innate and acquired immunity, However, the in vivo role of IL-12 in viral myocarditis remains to be elucidated. To clarify the role of IL-12 in viral myocarditis, we treated mice inoculated with the encephalomyocarditis virus (EMCV), with recombinant IL-12 and neutralizing anti-IL-12 antibody, The successive administration of 10 ng of IL-12 from the day of virus inoculation to 5 days thereafter, reduced mortality, myocardial damage and viral replication in the heart tissue. The gene expression of IL-12p35 and IL-12p40 was enhanced in the hearts of EMCV inoculated mice. Treatment with neutralizing anti-IL-12 resulted in increased mortality of mice inoculated with EMCV. In conclusion, endogenous and exogenous IL-12 play protective roles in murine viral myocarditis. (C) 1997 Academic Press Limited.

引用

页码：2327 / 2334

页数：8

共 37 条

[1]

CYTOKINES - COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES [J].