How biologics targeting the IL-1 system are being considered for the treatment of type 2 diabetes

被引：31

作者：

Boeni-Schnetzler, Marianne

Donath, Marc Y.

机构：

[1] Univ Basel Hosp, Clin Endocrinol Diabet & Metab, CH-204031 Basel, Switzerland

[2] Univ Basel Hosp, Dept Biomed, CH-204031 Basel, Switzerland

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2013年 / 76卷 / 02期

关键词：

cytokines; IL-1; type; 2; diabetes; inflammation; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ISLET-ASSOCIATED MACROPHAGES; BETA-CELL; INSULIN-RESISTANCE; NLRP3; INFLAMMASOME; ACTIVATION; IL-1-BETA; SECRETION; OBESITY; HYPERGLYCEMIA;

D O I：

10.1111/j.1365-2125.2012.04297.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Metabolic diseases are associated with activation of the innate immune system in various tissues and characterized by elevated inflammatory factors and the presence of immune cells. Type 2 diabetes develops when islet beta cells are deficient in producing sufficient insulin to overcome peripheral insulin resistance. Intra-islet IL-1 activity diminishes beta cell function and survival and governs islet inflammation. Targeting the IL-1 system with the IL-1 receptor antagonist IL1Ra improved insulin secretion, glycaemia and reduced systemic inflammation in a proof of concept study with patients with type 2 diabetes. Currently, long lasting and specific IL-1 blocking antibodies are being evaluated in clinical trials and this may lead to a novel cytokine-based treatment for type 2 diabetes.

引用

收藏

页码：263 / 268

页数：6

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