Modulating heteroplasmy

被引：23

作者：

Chinnery, PF ^{[1
]}

机构：

[1] Med Sch Newcastle Upon Tyne, Dept Neurol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 04期

关键词：

D O I：

10.1016/S0168-9525(01)02636-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Patients with mitochondrial DNA (mtDNA) disease usually harbor a mixture of mutant and wild-type mtDNA (a state termed heteroplasmy), and the clinical features of the disease depend on the percentage of mutant mtDNA (the,mutation load') invulnerable tissues. Factors that modulate the mutation load are poorly understood, but recent work has started to unravel the mechanisms. In certain circumstances heteroplasmy might be regulated at the level of the individual mitochondrial genome.

引用

页码：173 / 176

页数：4

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