Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence

被引：11

作者：

Filimonov, PN ^{[1
]}

Sukhenko, TG

Papantonopulo, AN

Gavrilova, NI

Shkurupii, VA

机构：

[1] Novosibirsk State Med Acad, Novosibirsk, Russia

[2] Russian Acad Med Sci, Siberian Div, Inst Clin Immunol, Moscow, Russia

[3] Russian Acad Med Sci, Siberian Div, Res Ctr Clin & Expt Med, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 140卷 / 06期

关键词：

heroin; liver fibrosis; age;

D O I：

10.1007/s10517-006-0066-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Young and middle-aged CBA mice were injected with "street" heroin in increasing doses for 14 days. Volume density of perisinusoid argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), spontaneous, LPS- and ConA-stimulated splenocyte proliferation decreased in young mice. Six months after heroin discontinuation further progress of liver fibrosis was observed in young mice.

引用

页码：723 / 725

页数：3

共 11 条

[1]

CELLULAR AND MATRIX CHANGES IN DRUG-ABUSER LIVER SINUSOIDS - A SEMIQUANTITATIVE AND MORPHOMETRIC ULTRASTRUCTURAL-STUDY [J].