Cognitive function across the life course and the menopausal transition in a British birth cohort

被引:80
作者
Kok, HS
Kuh, D
Cooper, R
van der Schouw, YT
Grobbee, DE
Wadsworth, MEJ
Richards, M
机构
[1] Royal Free & UCL, MRC Natl Survey Hlth & Dev, Dept Epidemiol & Publ Hlth, Sch Med, London WC1E 6BT, England
[2] Univ Utrecht, Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2006年 / 13卷 / 01期
基金
英国医学研究理事会;
关键词
menopause; menopausal transition; menopause age; cognition; epidemiology;
D O I
10.1097/01.gme.0000196592.36711.a0
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Despite biological plausibility, relationships between menopause and cognitive function are inconsistent. We investigated whether menopause status and menopause age were associated with general cognitive ability, verbal memory, and visual search speed and concentration in a large cohort of women while considering vasomotor and psychological symptoms, previous childhood and adult measures of cognitive function, lifetime socioeconomic circumstances, educational attainment, lifestyle factors, and chronic diseases. Design: A nationally representative British cohort of 1,261 women born in March 1946 and all aged 53 years at cognitive testing, with prospective information on previous cognitive function, menopausal characteristics, and potential confounders. Results: There was only weak evidence of the effect of natural menopause on cognitive function and no evidence of any effects of hormone therapy use or hysterectomy status. There was a trend across the phases of the natural menopausal transition (pre-, peri-, and postmenopause) for the National Adult Reading Test (P = 0.005) and search speed and concentration (P = 0.042), with postmenopausal women having the lowest cognitive function, but there was no trend in verbal memory. Variation in vasomotor and psychological symptoms did not explain these trends. In postmenopausal women, there was a positive trend across menopause age for verbal memory (P = 0.004) and a weak positive trend for the National Adult Reading Test (P = 0.052), with women who reached menopause later having higher cognitive function. Previous cognitive function generally explained the associations, which were further weakened by adjusting for socioeconomic and educational confounders. One exception was the association between the natural menopause transition and search speed and concentration, which remained after adjustment for these factors. Conclusion: Menopause adversely affects cognitive function, but this effect may be largely explained by premenopausal cognitive function. These findings suggest that common environmental or genetic factors, operating through long-term or lifelong hormonal mechanisms, may influence the timing of natural menopause and lifetime cognitive function.
引用
收藏
页码:19 / 27
页数:9
相关论文
共 72 条
  • [1] ANCELIN ML, 2004, CURR PHARM DESIGN
  • [2] [Anonymous], 1982, MINNESOTA CODE RESTI
  • [3] ESTROGEN REPLACEMENT THERAPY AND COGNITIVE FUNCTION IN OLDER WOMEN
    BARRETTCONNOR, E
    KRITZSILVERSTEIN, D
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (20): : 2637 - 2641
  • [4] Oestrogen as a neuroprotective hormone
    Behl, C
    [J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (06) : 433 - 442
  • [5] DEFINING THE PERIMENOPAUSE FOR APPLICATION IN EPIDEMIOLOGIC INVESTIGATIONS
    BRAMBILLA, DJ
    MCKINLAY, SM
    JOHANNES, CB
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1994, 140 (12) : 1091 - 1095
  • [6] Chrousos George P., 1998, Annals of Internal Medicine, V129, P229
  • [7] CROSS-SECTIONAL AND CASE-CONTROLLED ANALYSES OF THE ASSOCIATION BETWEEN SMOKING AND EARLY MENOPAUSE
    CRAMER, DW
    HARLOW, BL
    XU, HJ
    FRAER, C
    BARBIERI, R
    [J]. MATURITAS, 1995, 22 (02) : 79 - 87
  • [8] PREDICTION OF WAIS IQ WITH THE NATIONAL ADULT READING TEST - CROSS-VALIDATION AND EXTENSION
    CRAWFORD, JR
    PARKER, DM
    STEWART, LE
    BESSON, JAO
    DELACEY, G
    [J]. BRITISH JOURNAL OF CLINICAL PSYCHOLOGY, 1989, 28 : 267 - 273
  • [9] Department of Education and Science, 1972, BURNH FURTH ED COMM
  • [10] Conjugated equine estrogens and global cognitive function in postmenopausal women - Women's Health Initiative Memory Study
    Espeland, MA
    Rapp, SR
    Shumaker, SA
    Brunner, R
    Manson, JE
    Sherwin, BB
    Hsia, J
    Margolis, KL
    Hogan, PE
    Wallace, R
    Dailey, M
    Freeman, R
    Hays, J
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (24): : 2959 - 2968