Deletion of leukocyte mitochondrial DNA in bipolar disorder

被引：40

作者：

Kato, T ^{[1
]}

Takahashi, Y ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI,DEPT PSYCHIAT,OTSU,SHIGA 52021,JAPAN

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1996年 / 37卷 / 2-3期

关键词：

affective disorder; molecular genetics; mitochondrial DNA deletion; energy metabolism;

D O I：

10.1016/0165-0327(95)00050-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Leukocyte mitochondrial DNA (mtDNA) was examined in 35 patients with bipolar disorder by the nested PCR method to explore whether or not the 4977 base-pair deletion (common deletion) is found. The PCR product corresponding to the common deletion was found in 2 of 35 (5.7%) patients and none of 29 normal controls. It was confirmed by the primer shift PCR method that this PCR product was amplified from deleted mtDNA. These results suggest that more than a small percentage of patients with bipolar disorder might have deleted mtDNA and that this aberrant mtDNA might relate to pathophysiology of a subtype of bipolar disorder.

引用

页码：67 / 73

页数：7

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