Synthesis and antitumor activity of 3-arylisoquinoline derivatives

被引：19

作者：

Cho, WJ ^{[1
]}

Yoo, SJ ^{[1
]}

Park, MJ ^{[1
]}

Chung, BH ^{[1
]}

Lee, CO ^{[1
]}

机构：

[1] KOREA RES INST CHEM TECHNOL,SCREENING CTR,TAEJON 305606,SOUTH KOREA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1997年 / 20卷 / 03期

关键词：

antitumor activity; 3-arylisoquinoline derivatives;

D O I：

10.1007/BF02976155

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to study the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinoline-1(2H)-one (2), which has exhibited significant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested for in vitro antitumor activity against five different human cancer cell lines.

引用

页码：264 / 268

页数：5

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