Septic shock in older people: a prospective cohort study

被引：15

作者：

da Silva, Fabiano Pinheiro ^{[1
]}

Zampieri, Fernando Godinho ^{[1
]}

Barbeiro, Denise Frediani ^{[1
]}

Barbeiro, Hermes Vieira ^{[1
]}

Goulart, Alessandra Carvalho ^{[1
]}

Torggler Filho, Francisco ^{[1
]}

Velasco, Irineu Tadeu ^{[1
]}

da Cruz Neto, Luiz Monteiro ^{[1
]}

de Souza, Heraldo Possolo ^{[1
]}

Cesar Machado, Marcel Cerqueira ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Emergency Med, Sao Paulo, Brazil

来源：

IMMUNITY & AGEING | 2013年 / 10卷

基金：

巴西圣保罗研究基金会;

关键词：

Ageing; Sepsis; Inflammation; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS-INFECTION; AGE; SEPSIS; PATHOPHYSIOLOGY; INFLAMMATION; MORTALITY; RECEPTOR; CELLS;

D O I：

10.1186/1742-4933-10-21

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Background: Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals. Results: Here, we describe a prospective cohort study designed to analyze the immune profile of this population. Conclusion: Older people are as immunocompetent as the young individual, regarding the cytokines, chemokines and growth factors response to devastating infection.

引用

页数：5

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