Highly enantioseletive biginelli reaction using a new chiral ytterbium catalyst: Asymmetric synthesis of dihydropyrimidines

被引：255

作者：

Huang, YJ

Yang, FY

Zhu, CJ ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 47期

关键词：

D O I：

10.1021/ja056092f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The highly enantioselective three-component Biginelli condensation catalyzed by a recyclable chiral ytterbium triflate with a novel hexadentate amine phenol ligand containing a pyridyl group has been developed. A wide range of optically active dihydropyrimidines with remarkable pharmacological interest was obtained in high yields with good to excellent enantioselectivities under mild conditions. Copyright © 2005 American Chemical Society.

引用

页码：16386 / 16387

页数：2

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