Relationship between calcium-dependent potassium channel and ectopic spontaneous discharges of injured dorsal root ganglion neurons in the rat

被引:17
作者
Xing, JL [1 ]
Hu, SJ [1 ]
机构
[1] Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China
基金
中国国家自然科学基金;
关键词
dorsal root ganglion; ectopic spontaneous discharge; calcium-dependent potassium channel; neuron;
D O I
10.1016/S0006-8993(99)01682-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The ectopic spontaneous discharges (ESD) of single myelinated dorsal root fiber originated from the injured dorsal root ganglion (DRG) neurons were recorded in vivo. When [Ca2+](o) perfusing the injured DRG had been enhanced or caffeine been used, the ESD was inhibited in dose-dependent manner, while using Ni2+ or EGTA, the ESD facilitated. The increment of [K+](o) and the use of TEA could both facilitate the ESD in dose-dependent manner. Apamin, a special antagonist of calcium-dependent potassium channel (K(Ca)), had markedly increased the number of ESD. These results suggest that the generation of ESD has close relation to the activity of K(Ca) channel. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:218 / 221
页数:4
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