Hypoglycemic and Antioxidant Activities of Paeonol and Its Beneficial Effect on Diabetic Encephalopathy in Streptozotocin-Induced Diabetic Rats

被引:64
作者
Liu, Jiping [1 ,2 ]
Wang, Shuyuan [1 ]
Feng, Liang [3 ]
Ma, Dongying [1 ]
Fu, Qiang [1 ]
Song, Yu [1 ]
Jia, Xiaobin [3 ]
Ma, Shiping [1 ]
机构
[1] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 210009, Peoples R China
[2] Shaanxi Univ Chinese Med, Dept Pharmacol, Xianyang, Peoples R China
[3] Jiangsu Prov Acad Chinese Med, Key Lab New Drug Delivery Syst Chinese Mat Med, Nanjing 210028, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
AGEs; cognitive deficit; diabetic encephalopathy; NF-kappa B; oxidative stress; paeonol; RAGE; GLYCATION END-PRODUCTS; SEED PROANTHOCYANIDIN EXTRACTS; OXIDATIVE STRESS; CEREBRAL-CORTEX; HIPPOCAMPAL-NEURONS; D-GALACTOSE; NEUROTOXICITY; INFLAMMATION; PERFORMANCE; EXPRESSION;
D O I
10.1089/jmf.2012.2654
中图分类号
R914 [药物化学];
学科分类号
100705 [微生物与生化药学];
摘要
Diabetic encephalopathy (DE) is one of the severe complications in patients with diabetes mellitus. Paeonol, an active compound isolated from the root bark of Paeonia suffruticosa, has significant antidiabetic activity in vivo. However, its underlying beneficial effects on DE were unclear. In the present study, the protective activity of paeonol on DE was evaluated in streptozotocin (STZ)-induced diabetic rats. Paeonol at 50 and 100 mg/kg significantly increased body weight and decreased blood glucose levels, glycosylated serum proteins, and serum advanced glycation end products (AGEs) levels. Immunohistochemistry assays and Western blot analysis revealed a significant decrease in expressions on receptor for advanced glycation end products (RAGE) and nuclear factor kappa B (NF-kappa B) in hippocampus and cerebral cortical neurons after paeonol treatment. Furthermore, paeonol significantly increased glutathione content and remarkedly decreased induced nitric oxide synthase activity in hippocampus tissue. Our findings indicated that paeonol could improve the pathological damage of DE in STZ-induced diabetic rats. It might be associated with the modulating AGEs/RAGE/NF-kappa B pathway. This study suggested that paeonol might be a promising candidate for the prevention and treatment of DE.
引用
收藏
页码:577 / 586
页数:10
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