Aromatic constituents of Uvaria grandiflora

被引：32

作者：

Ankisetty, S

ElSohly, HN ^{[1
]}

Li, XC

Khan, SI

Tekwani, BL

Smillie, T

Walker, L

机构：

[1] Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, University, MS 38677 USA

[2] Univ Mississippi, Dept Pharmacol, Sch Pharm, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np050500b

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Grandiuvarone A ( 1) and grandiuvarins A-C (2-4) were isolated from the bark of Uvaria grandiflora. The structures of these new aromatic compounds were elucidated on the basis of spectroscopic analyses, especially 2D NMR techniques. Only compound 1 exhibited antileishmanial activity, with IC50/IC90 values of 0.7/1.5 mu g/mL. The positive controls pentamidine and amphotericin B had IC50/IC90 values of 1.6/6.6 and 0.17/0.34 mu g/mL, respectively.

引用

页码：692 / 694

页数：3

共 13 条

[1]

2 NEW C-BENZYLATED FLAVANONES FROM UVARIA-CHAMAE AND C-13 NMR ANALYSIS OF FLAVANONE METHYL ETHERS [J].