Genetic variations of BRCA1 and BRCA2 genes in dogs with mammary tumours

被引：35

作者：

Enginler, S. O. ^{[1
]}

Akis, I. ^{[2
]}

Toydemir, T. S. F. ^{[1
]}

Oztabak, K. ^{[2
]}

Haktanir, D. ^{[3
]}

Gunduz, M. C. ^{[1
]}

Kirsan, I. ^{[1
]}

Firat, I. ^{[3
]}

机构：

[1] Istanbul Univ, Fac Vet Med, Dept Obstet & Gynaecol, TR-34320 Istanbul, Turkey

[2] Istanbul Univ, Fac Vet Med, Dept Biochem, TR-34320 Istanbul, Turkey

[3] Istanbul Univ, Fac Vet Med, Dept Pathol, TR-34320 Istanbul, Turkey

来源：

VETERINARY RESEARCH COMMUNICATIONS | 2014年 / 38卷 / 01期

关键词：

Dog; Mammary tumour; BRCA1; BRCA2; Single nucleotide polymorphism; CANINE; POLYMORPHISM; MUTATIONS; MECHANISM; SILENT; RAD51; POPULATION; REPAIR; SITES; DNA;

D O I：

10.1007/s11259-013-9577-7

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

Mammary tumours are the most common tumour type in female dogs. The formation of the mammary tumours is multifactorial but the high incidence of tumour disease in certain canine breeds suggests a strong genetic component. BRCA1 and BRCA2 are the most important genes significantly associated with mammary tumours. The aim of this study was to determine the association between the variations of these two genes and canine mammary tumours. 5'-untranslated region, intron 8 and exon 9 of BRCA1 and exons 12, 24, 27 of BRCA2 were sequenced in order to detect the genetic variations. In addition to six previously identified polymorphisms, six novel single nucleotide polymorphisms (SNPs) were detected. Five of the coding SNPs were synonymous and three of them were non-synonymous. The comparison of the sequences from 25 mammary tumour bearing and 10 tumour free dogs suggested that the two SNPs in intron 8 and exon 9 of BRCA1 and two SNPs in exon 24 and exon 27 of BRCA2, which are firstly identified in this study, might be associated with mammary tumour development in dogs. Especially one SNP in exon 9 of BRCA1 and one SNP in exon 24 of BRCA2 were found to be significantly associated with canine mammary tumours.

引用

页码：21 / 27

页数：7

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