MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis

被引：96

作者：

Caporali, Andrea ^{[1
]}

Emanueli, Costanza ^{[1
]}

机构：

[1] Univ Bristol, Bristol Royal Infirm, Lab Vasc Pathol & Regenerat, Sch Clin Sci, Bristol BS2 8HW, Avon, England

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2011年 / 21卷 / 06期

基金：

英国医学研究理事会;

关键词：

ENDOTHELIAL-CELLS; MIR-16; FAMILY; STEM-CELLS; GENES; EXPRESSION; DIFFERENTIATION; IDENTIFICATION; CIRCUITRY; DISEASES; ARREST;

D O I：

10.1016/j.tcm.2012.05.003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence of the prominent role of miR-503 in impairment of postischemic reparative angiogenesis in the setting of diabetes. Because miR-503 belongs to the miR-16 extended family of miRs, in this review, we describe the cardiovascular functions of miR-503 and other members of the miR-16 family and their impact on angiogenesis. (Trends Cardiovasc Med 2011;21:162-166) (C) 2011 Elsevier Inc. All rights reserved.

引用

收藏

页码：162 / 166

页数：5

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