Probing Bacterial-Toxin Inhibition with Synthetic Glycopolymers Prepared by Tandem Post-Polymerization Modification: Role of Linker Length and Carbohydrate Density

被引:114
作者
Richards, Sarah-Jane [1 ]
Jones, Mathew W. [1 ]
Hunaban, Mark [1 ]
Haddleton, David M. [1 ]
Gibson, Matthew I. [1 ]
机构
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
基金
英国工程与自然科学研究理事会;
关键词
bioorganic polymers; carbohydrates; cholera toxin; click chemistry; glycoconjugates; CRYSTAL-STRUCTURE; CHOLERA-TOXIN; DC-SIGN; BINDING; LECTIN; LIGANDS; OLIGOSACCHARIDES; GLYCOPROTEIN; POLYMERS; DESIGN;
D O I
10.1002/anie.201202945
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:7812 / 7816
页数:5
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