Effect of age and carbon tetrachloride on cytokine concentrations in rat liver

被引：32

作者：

Rikans, LE

DeCicco, LA

Hornbrook, KR

Yamano, T

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Oklahoma City, OK 73190 USA

[2] Osaka City Inst Publ Hlth & Environm Sci, Osaka 543, Japan

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1999年 / 108卷 / 02期

关键词：

interleukin-1; beta; interleukin-6; tumor necrosis factor-alpha; carbon tetrachloride hepatotoxicity; rat liver;

D O I：

10.1016/S0047-6374(99)00012-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in livers of young-adult and old rats administered carbon tetrachloride or vehicle. IL-1 beta levels were higher and IL-6 levels were lower in old rats than in young-adult rats. Carbon tetrachloride treatment increased IL-1 beta and decreased TNF-alpha and IL-6. The elevation in IL-1 beta was diminished by aging. These results indicate that the increase in carbon tetrachloride hepatotoxicity that occurs in old age could be related to a dysregulation of inflammatory cytokines. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

收藏

页码：173 / 182

页数：10

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