HLA matching in pediatric recipients of a first kidney graft

被引:10
作者
Barocci, S
Valente, U
Gusmano, R
Torre, F
Basile, G
Fontana, I
Arcuri, V
Olmi, F
Angelini, G
Nocera, A
机构
[1] SAN MARTINO HOSP,DEPT IMMUNOL,I-16132 GENOA,ITALY
[2] SAN MARTINO HOSP,DEPT TRANSPLANT SURG,I-16132 GENOA,ITALY
[3] UNIV GENOA,I-16132 GENOA,ITALY
[4] IST GIANNINA GASLINI,DEPT PEDIAT NEPHROL,I-16148 GENOA,ITALY
关键词
D O I
10.1097/00007890-199601150-00029
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We retrospectively examined the effect of HLA-A, -B, and -DR serological matching on graft survival in 88 pediatric end-stage renal disease patients who underwent primary renal transplantation. Actuarial graft survivals (GS) at 2 and 6 years in patients with zero DR mismatches (MM) (12 patients) or 1 DR MM (58 patients) were significantly higher than those in patients with 2 DR MM (18 patients) (2-year GS: 100% vs. 90% vs. 59%; 6-year GS: 100% vs.79% vs. 59%, respectively), Because of the low number of patients in the zero DR MM group, only the GS difference between 1 DR MM and 2 DR MM had a significant result at 1 year (92% vs. 68%). No clear HLA matching effect was obtained in the HLA-A and -B loci, When DR were combined with A or B antigens (0-2 MM vs, 3-4 MM), significantly higher GS at 1, 2, and 6 years persisted for patients with 0-2 MM only in the A, DR group (96%, 94%, and 85% vs, 68%, 63%, and 56%, respectively). It is suggested that avoidance of mismatching for DR alleles at the serological level, in the selection of pediatric recipients of first cadaveric renal transplantation, leads to an improvement of both short- and long-term graft outcome.
引用
收藏
页码:151 / 154
页数:4
相关论文
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