Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale Presentation and Clinimetric Testing Results

被引：3766

作者：

Goetz, Christopher G. ^{[1
]}

Tilley, Barbara C. ^{[2
,15
]}

Shaftman, Stephanie R. ^{[2
,15
]}

Stebbins, Glenn T. ^{[1
]}

Fahn, Stanley ^{[3
]}

Martinez-Martin, Pablo ^{[4
,5
]}

Poewe, Werner ^{[6
]}

Sampaio, Cristina ^{[7
]}

Stern, Matthew B. ^{[8
]}

Dodel, Richard ^{[9
]}

Dubois, Bruno ^{[10
]}

Holloway, Robert ^{[11
]}

Jankovic, Joseph ^{[12
]}

Kulisevsky, Jaime ^{[13
,14
]}

Lang, Anthony E. ^{[16
]}

Lees, Andrew ^{[17
]}

Leurgans, Sue ^{[1
]}

LeWitt, Peter A. ^{[18
]}

Nyenhuis, David ^{[19
]}

Olanow, C. Warren ^{[20
,21
]}

Rascol, Olivier ^{[22
]}

Schrag, Anette ^{[23
]}

Teresi, Jeanne A. ^{[24
,25
]}

van Hilten, Jacobus J. ^{[26
]}

LaPelle, Nancy ^{[27
]}

机构：

[1] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[2] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[3] Columbia Univ, Dept Neurol, New York, NY USA

[4] Carlos III Inst Hlth, Neuroepidemiol Unit, Madrid, Spain

[5] Carlos III Inst Hlth, CIBERNED, Madrid, Spain

[6] Innsbruck Med Univ, Dept Neurol, Innsbruck, Austria

[7] Fac Med Lisbon, Dept Pharmacol, Lisbon, Portugal

[8] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[9] Univ Marburg, Dept Neurol, Marburg, Germany

[10] Hop La Pitie Salpetriere, Dept Neurol, Paris, France

[11] Univ Rochester, Dept Neurol, Rochester, NY USA

[12] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[13] St Pau Hosp, Dept Neurol, Barcelona, Spain

[14] St Pau Hosp, CIBERNED, Barcelona, Spain

[15] Med Univ S Carolina, Charleston, SC 29425 USA

[16] Univ Toronto, Div Neurol, Toronto, ON, Canada

[17] UCL, Reta Lila Weston Inst Neurol Studies, London, England

[18] Wayne State Univ, Dept Neurol, Detroit, MI USA

[19] Univ Illinois, Dept Neurol & Rehabil, Chicago, IL USA

[20] Mt Sinai Sch Med, Dept Neurol, New York, NY USA

[21] Mt Sinai Sch Med, Dept Neurosci, New York, NY USA

[22] Toulouse Univ, Lab Pharmacol Med & Clin, Toulouse, France

[23] UCL, Dept Clin Neurosci, London, England

[24] Columbia Univ, Stroud Ctr, Div Gen Med, New York, NY USA

[25] Columbia Univ, Inst Psychiat, New York, NY USA

[26] Leiden Univ, Dept Neurol, Leiden, Netherlands

[27] Univ Massachusetts, Div Prevent & Behav Med, Worcester, MA 01605 USA

来源：

MOVEMENT DISORDERS | 2008年 / 23卷 / 15期

关键词：

Parkinson's disease; rating scales; UPDRS; clinimetrics;

D O I：

10.1002/mds.22340

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, 1: Non-motor Experiences of Daily Living; 11: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and Study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha 0.79-0.93 across parts) and correlated with the original UPDRS (rho = 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD. (C) 2008 Movement Disorder Society

引用

页码：2129 / 2170

页数：42

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