Clinical and biological significance of RAS mutations in multiple myeloma

被引:128
作者
Chng, W. J. [1 ,6 ,7 ]
Gonzalez-Paz, N. [2 ]
Price-Troska, T. [2 ]
Jacobus, S. [3 ]
Rajkumar, S. V. [2 ]
Oken, M. M. [4 ]
Kyle, R. A. [2 ]
Henderson, K. J. [2 ]
Van Wier, S. [1 ]
Greipp, P. [2 ]
Van Ness, B. [5 ]
Fonseca, R. [1 ]
机构
[1] Mayo Clin, Dept Haematol Oncol, Scottsdale, AZ USA
[2] Mayo Clin, Div Haematol, Rochester, MN USA
[3] Dana Faber Canc Inst, Eastern Cooperat Oncol Grp, Ctr Stat, Boston, MA USA
[4] N Mem Canc Ctr, Dept Oncol, Minneapolis, MN USA
[5] Univ Minnesota, Dept Genet Cell Biol & Dev, Mineapolis, MN USA
[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore
[7] Natl Univ Singapore Hosp, Dept Haematol Oncol, Singapore 117548, Singapore
关键词
D O I
10.1038/leu.2008.142
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:2280 / 2284
页数:6
相关论文
共 8 条
[1]   High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis [J].
Bezieau, S ;
Devilder, MC ;
Avet-Loiseau, H ;
Mellerin, MP ;
Puthier, D ;
Pennarun, E ;
Rapp, MJ ;
Harousseau, JL ;
Moisan, JP ;
Bataille, R .
HUMAN MUTATION, 2001, 18 (03) :212-224
[2]   Genetic events in the pathogenesis of multiple myeloma [J].
Chng, W. J. ;
Glebov, O. ;
Bergsagel, R. L. ;
Kuehl, W. M. .
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2007, 20 (04) :571-596
[3]   Clinical significance of TP53 mutation in myeloma [J].
Chng, W. J. ;
Price-Troska, T. ;
Gonzalez-Paz, N. ;
Van Wier, S. ;
Jacobus, S. ;
Blood, E. ;
Henderson, K. ;
Oken, M. ;
Van Ness, B. ;
Greipp, P. ;
Rajkumar, S. V. ;
Fonseca, R. .
LEUKEMIA, 2007, 21 (03) :582-584
[4]   Clinical and biologic implications of recurrent genomic aberrations in myeloma [J].
Fonseca, R ;
Blood, E ;
Rue, M ;
Harrington, D ;
Oken, MM ;
Kyle, RA ;
Dewald, GW ;
Van Ness, B ;
Van Wier, SA ;
Henderson, KJ ;
Bailey, RJ ;
Greipp, PR .
BLOOD, 2003, 101 (11) :4569-4575
[5]   Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma? [J].
Greipp, PR ;
Trendle, MC ;
Leong, T ;
Oken, MM ;
Kay, NE ;
Van Ness, B ;
Kyle, RA .
LEUKEMIA & LYMPHOMA, 1999, 35 (1-2) :83-89
[6]   Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation [J].
Kalakonda, N ;
Rothwell, DG ;
Scarffe, JH ;
Norton, JD .
BLOOD, 2001, 98 (05) :1555-1560
[7]  
Oken MM, 1999, CANCER, V86, P957
[8]   Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors [J].
Rasmussen, T ;
Kuehl, M ;
Lodahl, M ;
Johnsen, HE ;
Dahl, IMS .
BLOOD, 2005, 105 (01) :317-323