Clinically silent PML and prolonged immune reconstitution inflammatory syndrome in a patient with multiple sclerosis treated with natalizumab

被引：16

作者：

Blinkenberg, Morten ^{[1
]}

Sellebjerg, Finn ^{[1
]}

Leffers, Anne-Mette ^{[2
]}

Madsen, Camilla Gobel ^{[2
]}

Sorensen, Per Soelberg ^{[1
]}

机构：

[1] Rigshosp, Copenhagen Univ Hosp, Danish Multiple Sclerosis Ctr, Dept Neurol, DK-2100 Copenhagen, Denmark

[2] Copenhagen Univ Hosp, Danish Res Ctr Magnet Resonance, Copenhagen, Denmark

来源：

MULTIPLE SCLEROSIS JOURNAL | 2013年 / 19卷 / 09期

基金：

英国医学研究理事会;

关键词：

PML; IRIS; multiple sclerosis; natalizumab; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; THERAPY;

D O I：

10.1177/1352458513481010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

We report the case of a woman with natalizumab-treated multiple sclerosis (MS) and clinically silent progressive multifocal leukoencephalopathy (PML) with an unusually long preclinical phase, followed by acute symptoms due to development of immune reconstitution inflammatory syndrome (IRIS). Furthermore, the course of the IRIS was prolonged and continued to progress even five months after natalizumab treatment was ceased. This case shows that PML and IRIS can have a considerably variable course in natalizumab-treated MS patients and underlines the need for PML screening in JC virus antibody-positive patients in order to detect clinically silent cases.

引用

收藏

页码：1226 / 1229

页数：4

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