Novel diamide-based inhibitors of IMPDH

被引：26

作者：

Gu, HH ^{[1
]}

Iwanowicz, EJ ^{[1
]}

Guo, JQ ^{[1
]}

Watterson, SH ^{[1
]}

Shen, ZQ ^{[1
]}

Pitts, WJ ^{[1
]}

Dhar, TGM ^{[1
]}

Fleener, CA ^{[1
]}

Rouleau, K ^{[1
]}

Sherbina, NZ ^{[1
]}

Witmer, M ^{[1
]}

Tredup, J ^{[1
]}

Hollenbaugh, D ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(02)00132-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase is described. The synthesis and the structure-activity relationships (SARs) derived front in vitro studies are presented. (C). 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1323 / 1326

页数：4

共 14 条

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