Iron Imports. III. Transfer of iron from the mucosa into circulation

被引:58
作者
Wessling-Resnick, M [1 ]
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2006年 / 290卷 / 01期
关键词
ferroportin; hephaestin; intestinal; iron transport;
D O I
10.1152/ajpgi.00415.2005
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Transfer of iron from the mucosa is a critical step in dietary iron assimilation that is tightly regulated to ensure the appropriate amount of iron is absorbed to meet the body's demands. Too much iron is highly toxic, and failure to properly control intestinal iron export causes iron overload associated with hereditary forms of hemochromatosis. One form of genetic iron overload, ferroportin disease, originates due to defects in ferroportin, the membrane iron exporter. Ferroportin acts in conjunction with the intestinal ferroxidase hephaestin to mediate release of iron from the enterocyte. How iron is then acquired by transferrin and released into circulation remains an unknown step in this process.
引用
收藏
页码:G1 / G6
页数:6
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