Magnesium supplementation in Gitelman syndrome

被引：37

作者：

Bettinelli, A ^{[1
]}

Basilico, E ^{[1
]}

Metta, MG ^{[1
]}

Borella, P ^{[1
]}

Jaeger, P ^{[1
]}

Bianchetti, MG ^{[1
]}

机构：

[1] Univ Milan, Dept Pediat 2, Milan, Italy

来源：

PEDIATRIC NEPHROLOGY | 1999年 / 13卷 / 04期

关键词：

Gitelman syndrome; magnesium deficiency; potassium deficiency; parathyroid hormone; vitamin D;

D O I：

10.1007/s004670050615

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

The metabolism of potassium and magnesium are closely linked (in situations where potassium and magnesium depletion coexist, magnesium restoration alone is sufficient to correct hypokalemia). Moreover, magnesium deficiency blunts the interplay between circulating calcium and the calciotropic hormones. Renal magnesium wasting, hypokalemia, alkalosis, hypocalciuria, and a tendency towards hypocalcemia characterize Gitelman syndrome. Plasma or intracellular potassium, circulating calcium, and calciotropic hormones were therefore investigated in eight patients (4 females, 4 males, aged 9-20 years) with Gitelman syndrome before and during oral supplementation with magnesium pyrrolidone carboxylate 30 mmol daily for 4 weeks. Magnesium supplementation significantly increased plasma and intracellular magnesium and plasma calcium, but failed to completely restore magnesium deficiency. In contrast, blood levels of parathyroid hormone and calcitriol and plasma and intracellular potassium were not modified following magnesium administration.

引用

页码：311 / 314

页数：4

共 18 条

[1]

GENETIC-HETEROGENEITY IN TUBULAR HYPOMAGNESEMIA HYPOKALEMIA WITH HYPOCALCURIA (GITELMANS SYNDROME) [J].