Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat

被引：231

作者：

Galli, J

Li, LS

Glaser, A

Ostenson, CG

Jiao, H

FakhraiRad, H

Jacob, HJ

Lander, ES

Luthman, H

机构：

[1] KAROLINSKA HOSP,DEPT MOLEC MED,ROLF LUFT CTR DIABET RES,S-17176 STOCKHOLM,SWEDEN

[2] MASSACHUSETTS GEN HOSP,CARDIOVASC RES CTR,BOSTON,MA 02129

[3] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[4] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

NATURE GENETICS | 1996年 / 12卷 / 01期

关键词：

D O I：

10.1038/ng0196-31

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.

引用

页码：31 / 37

页数：7

共 34 条

[1] IMPACT OF DIABETIC INHERITANCE ON GLUCOSE-TOLERANCE AND INSULIN-SECRETION IN SPONTANEOUSLY DIABETIC GK-WISTAR RATS [J].