Bone marrow-derived mesenchymal stem cells reduce brain amyloid-β deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease mouse model

被引：164

作者：

Lee, Jong Kil ^{[2
,3
]}

Jin, Hee Kyung ^{[2
,3
]}

Bae, Jae-sung ^{[1
,3
]}

机构：

[1] Kyungpook Natl Univ, Sch Med & Brain Korea 21, Dept Physiol, Lab Alzheimers Dis & Stem Cell, Taegu 700422, South Korea

[2] Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Taegu 700422, South Korea

[3] Kyungpook Natl Univ, Stem Cell Neuroplast Res Grp, Taegu 700422, South Korea

来源：

NEUROSCIENCE LETTERS | 2009年 / 450卷 / 02期

关键词：

Acutely induced Alzheimer's disease model; Bone marrow-derived mesenchymal stem cell; Amyloid-beta; Microglia; Transplantation; SYNAPTIC-TRANSMISSION; STROMAL CELLS; MICE; TRANSPLANTATION; PEPTIDE; NEURODEGENERATION; NEUROPROTECTION; PHAGOCYTOSIS; MECHANISMS; CLEARANCE;

D O I：

10.1016/j.neulet.2008.11.059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) has recently been explored in various pathological conditions of the central nervous system (CNS). However, the application of BM-MSCs in acutely induced Alzheimer's disease (AD) has not yet been reported. Herein the feasibility of using the BM-MSCs, as a therapeutic agent for AD has been tested. To assess this possibility, an acutely induced AD model induced by injecting amyloid-beta (A beta) into the dentate gyrus (DG) of hippocampus of C57BL/6 mice was used. Intracerebral transplantation of BM-MSCs into the brain of an induced AD model reduced their A beta levels when compared to sham-transplanted animals. The diminution of A beta deposits was accompanied by the activation of microglia. In addition, the activated microglia was located near the A beta deposits, and their morphology was changed from ramified to ameboid as a sign of microglial phagocytosis. This study provides evidence that BM-MSCs can promote the reduction of A beta through the microglial activation in this acutely induced AD brain, suggesting a potential therapeutic agent against AD. (C) 2008 Elsevier Ireland Ltd. All rights reserved

引用

页码：136 / 141

页数：6

共 24 条

[1]

Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration [J].