Cationic Thermosensitive Liposomes: A Novel Dual Targeted Heat-Triggered Drug Delivery Approach for Endothelial and Tumor Cells

被引：107

作者：

Dicheva, Bilyana M. ^{[1
]}

ten Hagen, Timo L. M. ^{[1
]}

Li, Li ^{[1
]}

Schipper, Debby ^{[1
]}

Seynhaeve, Ann L. B. ^{[1
]}

van Rhoon, Gerard C. ^{[2
]}

Eggermont, Alexander M. M. ^{[1
,5
]}

Lindner, Lars H. ^{[1
,3
,4
]}

Koning, Gerben A. ^{[1
]}

机构：

[1] Erasmus MC, Dept Surg, Sect Surg Oncol, Lab Expt Surg Oncol, Rotterdam, Netherlands

[2] Erasmus MC, Dept Radiotherapy, Unit Hyperthermia, Rotterdam, Netherlands

[3] Univ Munich, Univ Hosp Grosshadern, Dept Internal Med 3, Munich, Germany

[4] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, CCG Hyperthermia, Munich, Germany

[5] Inst Cancerol, Paris, France

来源：

NANO LETTERS | 2013年 / 13卷 / 06期

关键词：

Cationic thermosensitive liposomes; hyperthermia; triggered release; drug delivery; targeted nanomedicine; ANIONIC PHOSPHOLIPIDS; VASCULAR-PERMEABILITY; CONTENT RELEASE; IN-VITRO; DOXORUBICIN; ANTHRACYCLINES; HYPERTHERMIA; EFFICACY; SARCOMA; SURFACE;

D O I：

10.1021/nl3014154

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Developing selectively targeted and heat-responsive nanocarriers holds paramount promises in chemotherapy. We show that this can be achieved by designing liposomes combining cationic charged and thermosensitive lipids in the bilayer. We demonstrated, using flow cytometry, live cell imaging, and intravital optical imaging, that cationic thermosensitive liposomes specifically target angiogenic endothelial and tumor cells. Application of mild hyperthermia led to a rapid content release extra- and intracellularly in two crucial cell types in a solid tumor.

引用

页码：2324 / 2331

页数：8

共 35 条

[1]

Efficacy and safety of liposomal anthracyclines in phase I/II clinical trials [J].

Alberts, DS ;

Muggia, FM ;

Carmichael, J ;

Winer, EP ;

Jahanzeb, M ;

Venook, AP ;

Skubitz, KM ;

Rivera, E ;

Sparano, JA ;

Dibella, NJ ;

Stewart, SJ ;

Kavanagh, JJ ;

Gabizon, AA .

SEMINARS IN ONCOLOGY, 2004, 31 (06) :53-90

[2]

LIPOSOMES CONTAINING SYNTHETIC LIPID DERIVATIVES OF POLY(ETHYLENE GLYCOL) SHOW PROLONGED CIRCULATION HALF-LIVES INVIVO [J].

ALLEN, TM ;

HANSEN, C ;

MARTIN, F ;

REDEMANN, C ;

YAUYOUNG, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1066 (01) :29-36

[3]

Campbell RB, 2002, CANCER RES, V62, P6831

[4]

Fighting Cancer: From the Bench to Bedside Using Second Generation Cationic Liposomal Therapeutics [J].

Campbell, Robert B. ;

Ying, Bo ;

Kuesters, Geoffrey M. ;

Hemphill, Ryan .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 98 (02) :411-429

[5]

Rate of biodistribution of STEALTH® liposomes to tumor and skin:: influence of liposome diameter and implications for toxicity and therapeutic activity [J].

Charrois, GJR ;

Allen, TM .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1609 (01) :102-108

[6]

Importance of the liposomal cationic lipid content and type in tumor vascular targeting: Physicochemical characterization and in vitro studies using human primary and transformed endothelial cells [J].

Dabbas, Sudhir ;

Kaushik, Ritu R. ;

Dandamudi, Suman ;

Kuesters, Geoffrey M. ;

Campbell, Robert B. .

ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH, 2008, 15 (04) :189-201

[7]

Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors [J].

Dreher, Matthew R. ;

Liu, Wenge ;

Michelich, Charles R. ;

Dewhirst, Mark W. ;

Chilkoti, Ashutosh .

CANCER RESEARCH, 2007, 67 (09) :4418-4424

[8]

ELECTROSTATIC INTERACTIONS AT CHARGED LIPID-MEMBRANES - HYDROGEN-BONDS IN LIPID-MEMBRANE SURFACES [J].

EIBL, H ;

WOOLLEY, P .

BIOPHYSICAL CHEMISTRY, 1979, 10 (3-4) :261-271

[9]

Pharmacokinetics of pegylated liposomal doxorubicin - Review of animal and human studies [J].

Gabizon, A ;

Shmeeda, H ;

Barenholz, Y .

CLINICAL PHARMACOKINETICS, 2003, 42 (05) :419-436

[10]

GABIZON AA, 1992, CANCER RES, V52, P891

← 1 2 3 4 →