Regulation of the unfolded protein response by microRNAs

被引：56

作者：

Bartoszewska, Sylwia ^{[1
]}

Kochan, Kinga ^{[2
]}

Madanecki, Piotr ^{[2
]}

Piotrowski, Arkadiusz ^{[2
]}

Ochocka, Renata ^{[2
]}

Collawn, James F. ^{[3
]}

Bartoszewski, Rafal ^{[2
]}

机构：

[1] Med Univ Gdansk, Dept Inorgan Chem, PL-80416 Gdansk, Poland

[2] Med Univ Gdansk, Dept Biol & Pharmaceut Bot, PL-80416 Gdansk, Poland

[3] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL USA

来源：

CELLULAR & MOLECULAR BIOLOGY LETTERS | 2013年 / 18卷 / 04期

关键词：

MicroRNA; Unfolded protein response; Adaptive response; Endoplasmic reticulum stress; ENDOPLASMIC-RETICULUM STRESS; EUKARYOTIC TRANSLATION INITIATION; INHIBITS CELL-PROLIFERATION; ER-STRESS; MESSENGER-RNA; INDUCED APOPTOSIS; MIR-23A-SIMILAR-TO-27A-SIMILAR-TO-24-2; CLUSTER; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; DOWN-REGULATION;

D O I：

10.2478/s11658-013-0106-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The unfolded protein response (UPR) is an adaptive response to the stress that is caused by an accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER). It is an important component of cellular homeostasis. During ER stress, the UPR increases the protein-folding capacity of the endoplasmic reticulum to relieve the stress. Failure to recover leads to apoptosis. Specific cellular mechanisms are required for the cellular recovery phase after UPR activation. Using bioinformatics tools, we identified a number of microRNAs that are predicted to decrease the mRNA expression levels for a number of critical components of the UPR. In this review, we discuss the potential role of microRNAs as key regulators of this pathway and describe how microRNAs may play an essential role in turning off the UPR after the stress has subsided.

引用

页码：555 / 578

页数：24

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