DNA interaction of platinum(II) complexes with 1,10-phenanthroline and extended phenanthrolines

被引：88

作者：

Cusumano, M ^{[1
]}

Di Pietro, ML ^{[1
]}

Giannetto, A ^{[1
]}

机构：

[1] Univ Messina, Dipartimento Chim Inorgan, I-98166 Messina, Italy

来源：

INORGANIC CHEMISTRY | 2006年 / 45卷 / 01期

关键词：

D O I：

10.1021/ic050880o

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The interaction with DNA of the platinum(II) square planar complexes [Pt(N-N)(py)(2)](2+) (N-N = 1, 10-phenanthroline (phen), dipyrido[3,2-d-.2',3'- quinoxaline (dpq), dipyrido[3,2-a:2',3'-c]phenazine (dppz), benzodipyrido[b:3,2-h:2'3'-phenazine (bdppz)) has been investigated by means of absorption, circular and linear dichroism spectroscopy, DNA melting, and viscosity. In the presence of excess [DNA] all the complexes intercalate to the double helix. For those with the most extended phenanthrolines the binding mode depends on the [DNA]/[complex] ratio (q); at low q values the substances bind externally to DNA probably self-aggregating along the double helix. When the DNA concentration is large enough, the aggregate breaks up and the complex intercalates within the nucleobases. The complexes self-aggregate, without added DNA, in the presence of a large salt concentration.

引用

页码：230 / 235

页数：6

共 47 条

[1]

[Anonymous], 1994, J MOL RECOGNIT

[2] SYNTHESIS, CHARACTERIZATION, AND INTERACTION WITH DNA OF THE NOVEL METALLOINTERCALATOR CATIONIC COMPLEX (2,2'6',2''-TERPYRIDINE)METHYLPLATINUM(II) [J].

ARENA, G ;

SCOLARO, LM ;

PASTERNACK, RF ;

ROMEO, R .

INORGANIC CHEMISTRY, 1995, 34 (11) :2994-3002

[3] COOPERATIVE BINDING OF A PLATINUM METALLOINTERCALATION REAGENT TO POLY(A).POLY(U) [J].

BARTON, JK ;

LIPPARD, SJ .

BIOCHEMISTRY, 1979, 18 (12) :2661-2668

[4] TRIS(PHENANTHROLINE)RUTHENIUM(II) - STEREOSELECTIVITY IN BINDING TO DNA [J].

BARTON, JK ;

DANISHEFSKY, AT ;

GOLDBERG, JM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (07) :2172-2176

[5] Efficient DNA binding by optically pure ruthenium tris(bipyridyl) complexes incorporating carboxylic functionalities. Solution and structural analysis [J].

Caspar, R ;

Musatkina, L ;

Tatosyn, A ;

Amouri, H ;

Gruselle, M ;

Guyard-Duhayon, C ;

Duval, R ;

Cordier, C .

INORGANIC CHEMISTRY, 2004, 43 (25) :7986-7993

[6] Bis-intercalative dinuclear platinum(II) 6-phenyl-2,2′-bipyridine complexes exhibit enhanced DNA affinity but similar cytotoxicity compared to the mononuclear unit [J].

Chan, HL ;

Ma, DL ;

Yang, MS ;

Che, CM .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2003, 8 (07) :761-769

[7]

Che CM, 1999, CHEM-EUR J, V5, P3350, DOI 10.1002/(SICI)1521-3765(19991105)5:11<3350::AID-CHEM3350>3.3.CO

[8]

2-A

[9] CONFORMATION STUDIES ON SODIUM AND CESIUM SALTS OF CALF THYMUS DEOXYRIBONUCLEIC ACID (DNA) [J].

COHEN, G ;

EISENBER.H .

BIOPOLYMERS, 1966, 4 (04) :429-&

[10] A 1H NMR study of the DNA binding of ruthenium(II) polypyridyl complexes [J].

Collins, JG ;

Sleeman, AD ;

Aldrich-Wright, JR ;

Greguric, I ;

Hambley, TW .

INORGANIC CHEMISTRY, 1998, 37 (13) :3133-3141

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