Molecular regulation of cell death and therapeutic strategies for cell death induction in prostate carcinoma

被引：17

作者：

Gjertsen, BT

Logothetis, CJ

McDonnell, TJ

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA

来源：

CANCER AND METASTASIS REVIEWS | 1998年 / 17卷 / 04期

关键词：

prostate cancer; apoptosis; bcl-2; bax; p53;

D O I：

10.1023/A:1006170332301

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many of the common molecular alterations associated with prostate cancer progression involve genes known to regulate cell death susceptibility. The significance of these molecular events is discussed in the context of developing and implementing new strategies designed to restore cell death susceptibility in prostate cancer cells and overcome therapeutic resistance.

引用

页码：345 / 351

页数：7

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