Anti-HIV pronucleotides:: Sate versus phenyl as a protecting grow of AZT phosphoramidate derivatives

被引：12

作者：

Beltran, T

Egron, D

Lefebvre, I

Périgaud, C

Pompon, A

Gosselin, G

Aubertin, AM

Imbach, JL

机构：

[1] Univ Montpellier 2, Chim Bioorgan Lab, UMR CNRS USTL 5625, F-34095 Montpellier 5, France

[2] Univ Strasbourg 1, Inst Virol, INSERM U74, F-67000 Strasbourg, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041617

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We comparatively studied the decomposition pathways in CEM cell extract of several PHENYL phosphoramidate diesters of AZT. A correlation between anti-MIN activities in TK- cell lines and pharmacokinetic data has been observed. This study would help to design corresponding SATE phosphoramidate diesters which revealed potent anti-HIV properties.

引用

页码：973 / 975

页数：3

共 3 条

[1] Anti-HIV pronucleotides:: Decomposition pathways and correlation with biological activities [J].