Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs

被引：55

作者：

Dimas, K

Papadaki, A

Tsimplouli, C

Hatziantoniou, S

Alevizopoulos, K

Pantazis, P

Demetzos, C

机构：

[1] Acad Athens, Fdn Biomed Res, Lab Pharmacol Pharmacotechnol, Athens 11527, Greece

[2] Univ Athens, Sch Pharm, Dept Pharmaceut Technol, Athens, Greece

[3] Medexis SA, Athens, Greece

[4] Univ Oklahoma, Ctr Hlth Sci, Inst Canc Res, Oklahoma City, OK USA

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2006年 / 60卷 / 03期

关键词：

labdane diterpenes; sclareol; breast cancer cells; p53; apoptosis;

D O I：

10.1016/j.biopha.2006.01.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sclareol is a labdane-type diterpene that has demonstrated a significant cytotoxic activity against human leukemic cell lines. Here, we report the effect of sclareol against the human breast cancer cell lines MN1 and MDD2 derived from the parental cell line, MCF7. MN1 cells express functional p53, whereas MDD2 cells do not express p53. Flow cytometry analysis of the cell cycle indicated that sclareol was able to inhibit DNA synthesis induce arrest at the G(0/1) phase of the cycle apoptosis independent of p53. Sclareol-induced apoptosis was further assessed by detection of fragmented DNA in the cells. Furthermore, sclareol enhanced the activity of known anticancer drugs, doxorubicin, etoposide and cisplatinum, against MDD2 breast cancer cell line. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：127 / 133

页数：7

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