Hospitalizations associated with rotavirus gastroenteritis in the United States, 1993-2002

被引:99
作者
Charles, Myrna D.
Holman, Robert C.
Curns, Aaron T.
Parashar, Umesh D.
Glass, Roger I.
Bresee, Joseph S.
机构
[1] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Resp & Enter Virus Branch, Atlanta, GA 30333 USA
[2] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Off Director, Atlanta, GA 30333 USA
关键词
rotavirus; gastroenteritis; United States; hospitalizations;
D O I
10.1097/01.inf.0000215234.91997.21
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background : In the United States, rotavirus gastroenteritis remains a common disease of children that results in many hospitalizations, clinic visits and medical costs. It is a common cause of morbidity and is associated with a high economic burden in developing countries. Prevention of hospitalizations is the primary target of rotavirus vaccines. Methods: To update estimates of rotavirus hospitalization rates in the United States, we conducted a retrospective analysis of 10 years of national hospitalization data associated with gastroenteritis and used both direct and indirect methods to estimate the percentage of cases associated with rotavirus gastroenteritis. Results: During 1993-2002, an average of 18% of all hospitalizations with gastroenteritis among children < 5 years old were associated with rotavirus infection as determined by the rotavirus-specific International Classification of Diseases, 9th revision, Clinical Modification code. The annual proportion of rotavirus-associated hospitalizations increased from 15% in 1993-1995 to 21% in 2000-2002. Hospitalizations associated with rotavirus and those associated with nonspecific gastroenteritis had a marked wintertime seasonality and similar age distribution, which peaked among children between 3 and 24 months old. Using indirect estimation methods, 58,000 to 70,000 rotavirus-associated hospitalizations were estimated to occur each year in the United States. Conclusions: Rotavirus gastroenteritis remains an important cause of hospitalizations in the United States, and the rate has not declined from 1993 through 2002.
引用
收藏
页码:489 / 493
页数:5
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