Facile Pd-catalyzed cross-coupling of 2′-deoxyguanosine O6-arylsulfonates with arylboronic acids

被引：75

作者：

Lakshman, MK

Thomson, PF

Nuqui, MA

Hilmer, JH

Sevova, N

Boggess, B

机构：

[1] CUNY City Coll, Dept Chem, New York, NY 10031 USA

[2] Univ Notre Dame, Dept Chem & Biochem, Mass Spectrometry Facil, Notre Dame, IN 46556 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 09期

关键词：

D O I：

10.1021/ol025673w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] The O-6-(2-mesitylenesulfonyl) derivative of 2'-deoxyguanosine undergoes a facile palladium-mediated C-C cross-coupling with arylboronic acids. Demonstrating the general applicability of this method, the synthesis of a previously undescribed class of 2-amino-6-arylpurine 2'-deoxynucleosides has been accomplished. The study also describes an evaluation of the O-6-(2,4,6-trilsopropylphenylsulfonyl) and the O-6-(4-toluenesulfonyl) derivatives for the cross-coupling.

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页码：1479 / 1482

页数：4

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