The Gas6/TAM System and Multiple Sclerosis

被引：50

作者：

Bellan, Mattia ^{[1
,2
,3
]}

Pirisi, Mario ^{[1
,2
,3
]}

Sainaghi, Pier Paolo ^{[2
,3
]}

机构：

[1] Univ Piemonte Orientale, Dept Translat Med, UPO, Via Solaroli 17, I-28100 Novara, Italy

[2] Maggiore della Carita Hosp, Div Internal Med, Immunorheumatol Unit, I-28100 Novara, Italy

[3] Interdisciplinary Res Ctr Autoimmune Dis, IRCAD, I-28100 Novara, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 11期

关键词：

Gas6; TAM receptors; Axl; MerTK; Tyro3; multiple sclerosis; RECEPTOR TYROSINE KINASE; CENTRAL-NERVOUS-SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASE-DEPENDENT PATHWAY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CUPRIZONE-INDUCED DEMYELINATION; ACTIVATED PROTEIN-KINASE; TYRO-3 FAMILY RECEPTORS; VASCULAR SMOOTH-MUSCLE; GROWTH-ARREST; APOPTOTIC CELLS;

D O I：

10.3390/ijms17111807

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS.

引用

页数：15

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