Human lymphocyte micronucleus genotoxicity test with mixtures of phytochemicals in environmental concentrations

被引：24

作者：

BianchiSantamaria, A ^{[1
]}

Gobbi, M ^{[1
]}

Cembran, M ^{[1
]}

Arnaboldi, A ^{[1
]}

机构：

[1] UNIV PAVIA,C GOLGI INST GEN PATHOL,I-27100 PAVIA,ITALY

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1997年 / 388卷 / 01期

关键词：

human peripheral lymphocyte; micronucleus test; pesticide mixture; food-stuff;

D O I：

10.1016/S1383-5718(96)00128-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This study was carried out to assess the genotoxicity of mixtures of pesticides using the micronucleus test with human lymphocytes in culture. Benomyl, azinphos-methyl, diazinon, dimethoate, pirimiphos-methyl pesticides were tested at doses estimated from their daily intake (EDI) [1]. Benomyl is a carbamate fungicide, the other compounds are organophosphorous insecticides. The compounds were tested both separately and in combination. The results showed a weak genotoxicity for three of the four organophosphorous insecticides and for benomyl. The various mixtures did not give additive effects.

引用

页码：27 / 32

页数：6

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