Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally

被引：48

作者：

Capparelli, R

Ventimiglia, I

Roperto, S

Fenizia, D

Iannelli, D

机构：

[1] Univ Naples Federico II, Dept Immunol, I-80055 Naples, Italy

[2] Univ Naples Federico II, Sch Biotechnol, I-80055 Naples, Italy

[3] Univ Naples Federico II, Sch Vet Med, Dept Pathol, I-80055 Naples, Italy

[4] Univ Naples Federico II, Ist Zooprofilattico Sperimentale Mezzogiorno, I-80055 Naples, Italy

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2006年 / 12卷 / 03期

关键词：

bacteriophage therapy; Escherichia coli O157 : H7; in-vivo selection; mice; persistence;

D O I：

10.1111/j.1469-0691.2005.01340.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A bacteriophage lytic for Escherichia coli O157:H7 was isolated from bovine manure. Following in-vivo selection, the phage acquired the capacity to persist in the circulatory system of mice for at least 38 days. When mice were infected experimentally with E. coli O157:H7 (10(7) CFU/mouse), simultaneous injection of the mice with phage (10(8) PFU/mouse) cleared E. coli O157:H7 from the mice within 48 h.

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收藏

页码：248 / 253

页数：6

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