Small lungs and suspect smooth muscle: congenital diaphragmatic hernia and the smooth muscle hypothesis

被引：27

作者：

Jesudason, EC ^{[1
]}

机构：

[1] Univ Liverpool, Alder Hey Childrens Hosp, Dept Paediat Surg, Inst Child Hlth, Liverpool L69 3BX, Merseyside, England

[2] Univ Liverpool, Div Child Hlth, Sch Reprod & Dev Med, Liverpool L69 3BX, Merseyside, England

来源：

JOURNAL OF PEDIATRIC SURGERY | 2006年 / 41卷 / 02期

基金：

英国医学研究理事会;

关键词：

airway smooth muscle; lung branching morphogenesis; congenital diaphragmatic hernia;

D O I：

10.1016/j.jpedsurg.2005.11.021

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Lung hypoplasia and congenital diaphragmatic hernia (CDH) represent an unsolved clinical and scientific problem. Early lung morphogenesis is coupled to development and function Of Pulmonary smooth niuscle. Activity of the latter is abnormal from the earliest stages of hypoplastic lung development and before supervening CDH. A "smooth Muscle hypothesis" is advanced to help explain embryonic lung malformations, fetal failure of lung growth, and postnatal susceptibility to barotrauma, airway hyperreactivity, and pulmonary hypertension in CDH. Exploring the interaction of smooth Muscle function and airway pressures may help optimise tracheal occlusion and provide support for both an adequately powered trial of glucocorticoids and also for experiniental "preventilation" strategies in fetal CDH. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：431 / 435

页数：5

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