Discourse production following injury to the dorsolateral prefrontal cortex

被引:46
作者
Coelho, Carl [1 ]
Le, Karen [1 ]
Mozeiko, Jennifer [1 ]
Krueger, Frank [2 ]
Grafman, Jordan [3 ]
机构
[1] Univ Connecticut, Speech Language & Hearing Sci Dept, Storrs, CT 06269 USA
[2] George Mason Univ, Mol Neurosci Dept, Fairfax, VA 22030 USA
[3] Rehabil Inst Chicago, Brain Injury Res Program, Chicago, IL 60611 USA
关键词
Dorsolateral prefrontal cortex; Discourse production; Language production; Discourse analysis; Working memory; CLOSED-HEAD-INJURY; TRAUMATIC BRAIN-INJURY; WORKING-MEMORY; EXECUTIVE FUNCTIONS; ELICITATION TASK; LANGUAGE; NARRATIVES; ABILITIES; CHILDREN; LESIONS;
D O I
10.1016/j.neuropsychologia.2012.09.005
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学(含古人类学)];
摘要
Individuals with damage. to the prefrontal cortex, and the dorsolateral prefrontal cortex (DLPFC) in particular, often demonstrate difficulties with the formulation of complex language not attributable to aphasia. The present study employed a discourse analysis procedure to characterize the language of individuals with left (L) or right (R) DLPFC lesions. All participants were 30-35 years post-onset of injury and presented with persistent discourse impairments. The discourse performance of the R DLPFC group was not significantly different from either the L DLPFC group or the non-injured comparison group. Individuals from the L DLPFC group demonstrated specific difficulties with narrative coherence and inclusion of critical story components. Both measures were significantly different from the comparison group. The discourse ability of the DLPFC groups was significantly correlated with measures of working memory. Findings support the use of discourse analysis for examining language impairments in individuals with PFC lesions. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3564 / 3572
页数:9
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