Role of aromatase in endometrial disease

被引:92
作者
Bulun, SE
Yang, SJ
Fang, ZJ
Gurates, B
Tamura, M
Zhou, JF
Sebastian, S
机构
[1] Univ Illinois, Dept Obstet & Gynecol, Chicago, IL 60612 USA
[2] Univ Illinois, Dept Mol Genet, Chicago, IL 60612 USA
关键词
aromatase; aromatase inhibitor; endometrium; endometriosis; estrogen; estrogen biosynthesis; estrogen metabolism; 17 beta-hydroxysteroid dehydrogenase type 2 steroidogenesis; osteoporosis; progesterone;
D O I
10.1016/S0960-0760(01)00134-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aromatase is the key enzyme for estrogen biosynthesis. It is normally expressed in the human ovary, skin, adipose tissue and brain. Aromatase activity is not detectable in normal endometrium. In contrast, aromatase is expressed aberrantly in endometriosis and is stimulated by PGE(2). This results in local production of estrogen, which induces PGE(2) formation and establishes a positive feedback cycle. Another abnormality in endometriosis, i.e. deficient 17beta-hyroxysteroid dehydro genase (17beta-HSD) type 2 expression, impairs the inactivation of estradiol to estrone. These molecular aberrations collectively favor accumulation of increasing quantities of estradiol and PGE(2) in endornetriosis. The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of post-menopausal endometriosis using an aromatase inhibitor. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码:19 / 25
页数:7
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