Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex

被引:16
作者
Espey, MG
Ellis, RJ
Heaton, RK
Basile, AS
机构
[1] NIDDKD, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA
[2] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
[4] HIV Neurobeh Res Ctr, San Diego, CA USA
关键词
CSF; HIV; HIV-1 associated dementia complex;
D O I
10.1212/WNL.53.5.1144
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Chronic hyperactivation of excitatory amino acid pathways in the CNS of patients infected with HIV-1 may contribute to the pathogenesis of HIV-l-associated dementia complex. However, no correlation between the concentration of glutamate in CSF (mean 3.3 mu mol/L) and either HIV-1 infection or HTV-1-associated dementia complex was observed. The results clarify several important issues regarding analysis of glutamate in the CSF and the role of excitotoxins in HIV-1-associated dementia complex.
引用
收藏
页码:1144 / 1145
页数:2
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