Effect of dexamethasone on bovine airway smooth muscle cell proliferation

被引：17

作者：

Dixon, ER ^{[1
]}

Weinberg, JA ^{[1
]}

Lew, B ^{[1
]}

机构：

[1] Univ Tennessee, Coll Med, Lebonheur Childrens Med Ctr, Crippled Childrens Fdn Res Ctr,Dept Pediat, Memphis, TN USA

来源：

JOURNAL OF ASTHMA | 1999年 / 36卷 / 06期

关键词：

steroids; airway smooth muscle; proliferation; asthma;

D O I：

10.3109/02770909909054558

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Airway smooth muscle proliferation is a key component of airway wall remodelling that occurs as a consequence of inflammation in asthma. Studies were conducted to examine the effect of dexamethasone on airway smooth muscle cell (ASMC) proliferation in vitro. Dexamethasone (25-250 nM) significantly inhibited DNA synthesis and cell division induced by beta-hexosaminidase A (Hex A, 50 nM) in bovine ASMC. The inhibitory effect of dexamethasone on DNA synthesis was variable depending on the growth factors: significant effect was observed on Hex A and insulin; no significant effect was observed on epidermal growth factor and fetal bovine serum.

引用

收藏

页码：519 / 525

页数：7

相关论文

共 35 条

[1] IMMUNOSUPPRESSION BY GLUCOCORTICOIDS - INHIBITION OF NF-KAPPA-B ACTIVITY THROUGH INDUCTION OF I-KAPPA-B SYNTHESIS [J].

AUPHAN, N ;

DIDONATO, JA ;

ROSETTE, C ;

HELMBERG, A ;

KARIN, M .

SCIENCE, 1995, 270 (5234) :286-290

[2]

BIAN XP, 1992, J DEV PHYSIOL, V17, P289

[3] TRYPTASE-INDUCED MITOGENESIS IN AIRWAY SMOOTH-MUSCLE CELLS - POTENCY, MECHANISMS, AND INTERACTIONS WITH OTHER MAST-CELL MEDIATORS [J].

BROWN, JK ;

JONES, CA ;

TYLER, CL ;

RUOSS, SJ ;

HARTMANN, T ;

CAUGHEY, GH .

CHEST, 1995, 107 (03) :S95-S96

[4]

COLLADOESCOBAR D, 1990, J IMMUNOL, V144, P3449

[5] GLUCOCORTICOIDS REGULATE THE AMOUNT OF G-PROTEINS IN RAT AORTA [J].

HAIGH, RM ;

JONES, CT ;

MILLIGAN, G .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 1990, 5 (02) :185-188

[6] HYPERPLASIA OF BRONCHIAL MUSCLE IN ASTHMA [J].

HEARD, BE ;

HOSSAIN, S .

JOURNAL OF PATHOLOGY, 1973, 110 (04) :319-+

[7] HYPEROXIA-INDUCED AIRWAY REMODELING IN IMMATURE RATS - CORRELATION WITH AIRWAY RESPONSIVENESS [J].

HERSHENSON, MB ;

GARLAND, A ;

KELLEHER, MD ;

ZIMMERMANN, A ;

HERNANDEZ, C ;

SOLWAY, J .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (05) :1294-1300

[8] Glucocorticoids reduce tachykinin NK2 receptor expression in bovine tracheal smooth muscle [J].

Katsunuma, T ;

Mak, JCW ;

Barnes, PJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 344 (01) :99-106

[9] GUINEA-PIG OZONE-INDUCED AIRWAY HYPERREACTIVITY IS ASSOCIATED WITH INCREASED N-ACETYL-BETA-D-GLUCOSAMINIDASE ACTIVITY IN BRONCHOALVEOLAR LAVAGE FLUID [J].

LEW, DB ;

CHODIMELLA, V ;

MURLAS, CG .

LUNG, 1990, 168 (05) :273-283

[10] A MANNOSE RECEPTOR MEDIATES MANNOSYL-RICH GLYCOPROTEIN-INDUCED MITOGENESIS IN BOVINE AIRWAY SMOOTH-MUSCLE CELLS [J].

LEW, DB ;

SONGUMIZE, E ;

PONTOW, SE ;

STAHL, PD ;

RATTAZZI, MC .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (05) :1855-1863

← 1 2 3 4 →