Lipoxins: Potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease

被引：83

作者：

Kieran, NE

Maderna, P

Godson, C ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Med & Therapeut, Dublin 4, Ireland

[2] Mater Misericordiae Univ Hosp, Dept Med & Therapeut, Dublin, Ireland

[3] Dublin Mol Med Ctr, Dublin, Ireland

来源：

KIDNEY INTERNATIONAL | 2004年 / 65卷 / 04期

基金：

英国惠康基金;

关键词：

lipoxins; eicosanoids; anti-inflammatory; acute renal failure; glomerulonephritis;

D O I：

10.1111/j.1523-1755.2004.00487.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Lipoxins are lipoxygenase-derived lipid mediators with both anti-inflammatory and proresolution properties that have been demonstrated in vivo and in vitro. The bioactivity profile of lipoxins in vitro suggests that they have therapeutic potential in acute renal failure and glomerulonephritis; predictions that have been borne out to date in experimental models of renal disease. We review recent developments on the molecular basis of lipoxin bioactions mediated through receptor crosstalk and the accumulating evidence that lipoxins may have potential as novel anti-inflammatory agents.

引用

收藏

页码：1145 / 1154

页数：10

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