Emerging restorative treatments for Parkinson's disease

被引：118

作者：

Deierborg, Tomas ^{[1
]}

Soulet, Denis ^{[1
]}

Roybon, Laurent ^{[1
]}

Hall, Vanessa ^{[1
]}

Brundin, Patrik ^{[1
]}

机构：

[1] Wallenberg Neurosci Ctr, Neuronal Survival Unit, BMC A10, Dept Expt Med Sci, S-22184 Lund, Sweden

来源：

PROGRESS IN NEUROBIOLOGY | 2008年 / 85卷 / 04期

基金：

瑞典研究理事会;

关键词：

Parkinson's disease; therapy; stem cell; transplantation; growth factor; GDNF; neurogenesis; transcription factor; embryonic; fetal; graft; striatum; substantia nigra;

D O I：

10.1016/j.pneurobio.2008.05.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and embryonic stem cells. to differentiate into dopaminergic neurons. Finally, we discuss adult neurogenesis as a potential tool for restoring lost dopamine neurons in patients suffering from Parkinson's disease. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：407 / 432

页数：26

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