Plasma TGF-β1, TIMP-1, MMP-1 and IL-18 as a combined biomarker of psoriasis activity

被引：51

作者：

Flisiak, Iwona ^{[1
]}

Zaniewski, Przemyslaw ^{[1
]}

Chodynicka, Bozena ^{[1
]}

机构：

[1] Med Univ Bialystok, Dept Dermatol & Venerol, PL-15540 Bialystok, Poland

来源：

BIOMARKERS | 2008年 / 13卷 / 05期

关键词：

TGF-beta; 1; TMIP-1; MMP-1; IL-18; psoriasis; PASI;

D O I：

10.1080/13547500802033300

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Plasma levels of transforming growth factor (TGF)-beta(1), tissue inhibitors of metalloproteinases (TIMP)-1, matrix metalloproteinase (MMP)-1 and interleukin (IL)-18 when analyzed separately demonstrate an association with psoriasis severity and treatment efficacy. To determine the highest correlation with the Psoriasis Area and Severity Index (PASI) score we carried out an analysis of these four proteins combined as the TTMI score. Concentrations of proteins were measured using an enzyme immunoassay in the plasma of 32 patients with chronic plaque-type psoriasis. The concentration of each biomarker was multiplied by the respective coefficient and the final individual TTMI score was the sum of these four values. TGF-beta(1), TIMP-1 and IL-18 demonstrated significant positive correlation, whereas MMP-1 demonstrated significant negative correlation with the PASI score. The TTMI score calculated for individual patients varied from -79 620 to 145713 (43 050 +/- 8081) and demonstrated significant correlation with the PASI score. The lowest TTMI mean value was observed in patients with a PASI score < 16 and the highest value was in patients with a PASI score > 20. The combined measurement of plasma TGF-beta(1), TIMP-1, MMP-1 and IL-18 has superior value as a biomarker of psoriasis activity in comparison with their separate analysis.

引用

页码：549 / 556

页数：8

共 30 条

[1] Serum levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17 and IL-18 in patients with active psoriasis and correlation with disease severity [J].

Arican, O ;

Aral, M ;

Sasmaz, S ;

Ciragil, P .

MEDIATORS OF INFLAMMATION, 2005, (05) :273-279

[2] TGF-β1 gene polymorphism in psoriasis vulgaris [J].

Baran, Wojcech ;

Szepietowski, Jacek C. ;

Mazur, Grzegorz ;

Baran, Eugeniusz .

CYTOKINE, 2007, 38 (01) :8-11

[3] Transforming growth factor-beta receptor binding and function are decreased in psoriatic dermal endothelium [J].

Cai, JP ;

Falanga, V ;

Taylor, JR ;

Chin, YH .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (02) :225-231

[4] The effect of narrowband ultraviolet B on the expression of matrix metalloproteinase-1, transforming growth factor-β1 and type I collagen in human skin fibroblasts [J].

Choi, C. P. ;

Kim, Y. I. ;

Lee, J. W. ;

Lee, M. H. .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2007, 32 (02) :180-185

[5]

Companjen A, 2004, EUR CYTOKINE NETW, V15, P210

[6]

Companjen AR, 2000, EUR CYTOKINE NETW, V11, P383

[7] Plasma and scales levels of interleukin 18 in comparison with other possible clinical and laboratory biomarkers of psoriasis activity [J].

Flisiak, I ;

Klepacki, A ;

Chodynicka, B .

BIOMARKERS, 2006, 11 (02) :194-200

[8] Effect of psoriasis activity on metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in plasma and lesional scales [J].

Flisiak, I ;

Porebski, P ;

Chodynicka, B .

ACTA DERMATO-VENEREOLOGICA, 2006, 86 (01) :17-21

[9] Effect of psoriasis treatment on plasma concentrations of metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 [J].

Flisiak, I ;

Mysliwiec, H ;

Chodynicka, B .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2005, 19 (04) :418-421

[10] Plasma transforming growth factor β1 as a biomarker of psoriasis activity and treatment efficacy [J].

Flisiak, I ;

Porebski, P ;

Flisiak, R ;

Chodynicka, B .

BIOMARKERS, 2003, 8 (05) :437-443

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