Single molecule photo-bleaching observed by surface enhanced resonant Raman scattering (SERRS)

被引：61

作者：

Maher, RC ^{[1
]}

Cohen, LF ^{[1
]}

Etchegoin, P ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Blackett Lab, London SW7 2BZ, England

来源：

CHEMICAL PHYSICS LETTERS | 2002年 / 352卷 / 5-6期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0009-2614(01)01474-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Single molecule photo-bleaching of Rhodamine 6G (RH6G) dye molecules is observed by surface enhanced resonant Raman scattering in gold (Au) colloids under double resonant excitation conditions. The effect is revealed through a breakdown in the normal exponential decay of the dye population at extremely low concentrations. Step-like structures in the decay of the Raman signals show that individual molecules are being destroyed as a function of time. This arrangement allows a study of photochemical degradation at single molecular level, and creates the possibility for the determination of absolute enhancement factors in the Raman cross-sections. (C) 2002 Published by Elsevier Science B.V.

引用

页码：378 / 384

页数：7

共 19 条

[1]

ARYA K, 1984, LIGHT SCATTERING SOL, V4, P419

[2] Raman and SERS microspectroscopy on living cells: a promising tool towards cellular-drug response and medical diagnosis [J].

Beljebbar, A ;

Sockalingum, GD ;

Morjani, H ;

Manfait, M .

BIOMEDICAL APPLICATIONS OF RAMAN SPECTROSCOPY, PROCEEDINGS OF, 1999, 3608 :175-184

[3]

Bohren C. F., 1998, ABSORPTION SCATTERIN

[4] Peptide and small molecule microarray for high throughput cell adhesion and functional assays [J].

Falsey, JR ;

Renil, M ;

Park, S ;

Li, SJ ;

Lam, KS .

BIOCONJUGATE CHEMISTRY, 2001, 12 (03) :346-353

[5] RAMAN-SPECTRA OF PYRIDINE ADSORBED AT A SILVER ELECTRODE [J].

FLEISCHMANN, M ;

HENDRA, PJ ;

MCQUILLAN, AJ .

CHEMICAL PHYSICS LETTERS, 1974, 26 (02) :163-166

[6] Kinetic control of interparticle spacing in Au colloid-based surfaces: Rational nanometer-scale architecture [J].

Grabar, KC ;

Smith, PC ;

Musick, MD ;

Davis, JA ;

Walter, DG ;

Jackson, MA ;

Guthrie, AP ;

Natan, MJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (05) :1148-1153

[7] Selective detection of deoxyribonucleic acid at ultralow concentrations by SERRS [J].

Graham, D ;

Smith, WE ;

Linacre, AMT ;

Munro, CH ;

Watson, ND ;

White, PC .

ANALYTICAL CHEMISTRY, 1997, 69 (22) :4703-4707

[8] Near-field Raman scattering enhanced by a metallized tip [J].

Hayazawa, N ;

Inouye, Y ;

Sekkat, Z ;

Kawata, S .

CHEMICAL PHYSICS LETTERS, 2001, 335 (5-6) :369-374

[9] Population pumping of excited vibrational states by spontaneous surface-enhanced Raman scattering [J].

Kneipp, K ;

Wang, Y ;

Kneipp, H ;

Itzkan, I ;

Dasari, RR ;

Feld, MS .

PHYSICAL REVIEW LETTERS, 1996, 76 (14) :2444-2447

[10] Single molecule detection using surface-enhanced Raman scattering (SERS) [J].

Kneipp, K ;

Wang, Y ;

Kneipp, H ;

Perelman, LT ;

Itzkan, I ;

Dasari, R ;

Feld, MS .

PHYSICAL REVIEW LETTERS, 1997, 78 (09) :1667-1670

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