Neurobiology - Young receptors make smart mice

被引:23
作者
Bliss, TVP [1 ]
机构
[1] Natl Inst Med Res, Div Neurophysiol, London NW7 1AA, England
关键词
D O I
10.1038/43333
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Long-term potentiation (LTP) in a region of the brain called the hippocampus is thought to underlie some forms of learning and memory. Fresh evidence for this theory comes from studies of transgenic mice that have been engineered to overexpress a subunit of the NMDA receptor called NR2B. These mice are not only smarter than usual, but they do, indeed, show enhanced LTP.
引用
收藏
页码:25 / 27
页数:3
相关论文
共 14 条
[1]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[2]   Neurotransmitter aberrations in schizophrenia: New perspectives and therapeutic implications [J].
Carlsson, A ;
Hansson, LO ;
Waters, N ;
Carlsson, ML .
LIFE SCIENCES, 1997, 61 (02) :75-94
[3]   DEVELOPMENTAL ONSET OF LONG-TERM POTENTIATION IN AREA CA1 OF THE RAT HIPPOCAMPUS [J].
HARRIS, KM ;
TEYLER, TJ .
JOURNAL OF PHYSIOLOGY-LONDON, 1984, 346 (JAN) :27-&
[4]  
Hebb D, 1949, ORG BEHAV
[5]   Enhanced LTP in mice deficient in the AMPA receptor GluR2 [J].
Jia, ZP ;
Agopyan, N ;
Miu, P ;
Xiong, ZG ;
Henderson, J ;
Gerlai, R ;
Taverna, FA ;
Velumian, A ;
MacDonald, J ;
Carlen, P ;
AbramowNewerly, W ;
Roder, J .
NEURON, 1996, 17 (05) :945-956
[6]   Facilitation of long-term potentiation and memory in mice lacking nociception receptors [J].
Manabe, T ;
Noda, Y ;
Mamiya, T ;
Katagiri, H ;
Houtani, T ;
Nishi, M ;
Noda, T ;
Takahashi, T ;
Sugimoto, T ;
Nabeshima, T ;
Takeshima, H .
NATURE, 1998, 394 (6693) :577-581
[7]  
MARTIN SJ, IN PRESS ANN REV NEU
[8]   Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein [J].
Migaud, M ;
Charlesworth, P ;
Dempster, M ;
Webster, LC ;
Watabe, AM ;
Makhinson, M ;
He, Y ;
Ramsay, MF ;
Morris, RGM ;
Morrison, JH ;
O'Dell, TJ ;
Grant, SGN .
NATURE, 1998, 396 (6710) :433-439
[9]   Mice with reduced NMDA receptor expression display behaviors related to schizophrenia [J].
Mohn, AR ;
Gainetdinov, RR ;
Caron, MG ;
Koller, BH .
CELL, 1999, 98 (04) :427-436
[10]   DEVELOPMENTAL AND REGIONAL EXPRESSION IN THE RAT-BRAIN AND FUNCTIONAL-PROPERTIES OF 4 NMDA RECEPTORS [J].
MONYER, H ;
BURNASHEV, N ;
LAURIE, DJ ;
SAKMANN, B ;
SEEBURG, PH .
NEURON, 1994, 12 (03) :529-540